Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis.
نویسندگان
چکیده
منابع مشابه
The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease
The transformation of lupus nephritis from one histologic pattern to another is well described. We report a case of a patient who initially presented with diffuse proliferative glomerulonephritis and was treated with prednisone and mycophenolate mofetil (MMF). She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. A repeat b...
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Background & Aims: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by various autoantibodies formation and immune complex deposition in various organs. Lupus nephritis is a common and severe manifestation of SLE that can lead to end stage renal disease and death. The aim of this study was to evaluate the long-term efficacy of cyclosporine A in the treat...
متن کاملUnderstanding lupus nephritis: diagnosis, management, and treatment options
Systemic lupus erythematosus (SLE) predominantly affects women in their reproductive years. Renal disease (glomerulonephritis) is one of the most frequent and serious manifestations of SLE. Of the various histological types of lupus glomerulonephritis, diffuse proliferative nephritis carries the worst prognosis. Combined with high-dose prednisone, mycophenolate mofetil (MMF) has emerged as a fi...
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Received: 18 Aug, 2008 Accepted: 14 Feb, 2009 Abstract Renal involvement is one of the most serious sequela of Henoch-Schönlein purpura. The presence of proteinuria (nephritic range) and hematuria is also associated with progression to renal insufficiency. In fifty percent of patients who display a combination of nephritis-nephrotic symptoms, end-stage disease develops. Pharmacologic treatme...
متن کاملRituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study.
BACKGROUND Subsequent to cyclophosphamide-based induction therapy of lupus nephritis, and despite maintenance chronic immunosuppressive treatment, many patients experience relapses. METHODS This prospective, observational study included 10 women with biopsy-proven relapse of proliferative lupus nephritis occurring during maintenance with mycophenolate mofetil (MMF) or azathioprine. The long-t...
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ورودعنوان ژورنال:
- The New England journal of medicine
دوره 344 5 شماره
صفحات -
تاریخ انتشار 2001